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Recommended Vaccinations for Large Animals


  • Calves:
  1. 2-4 Months: Dehorn, Castrate bull calves.
  2. 4 Months: 7way blackleg, IBR, BVD, BRSV, PI3, (modified live vaccine MLV). *See CAUTION NOTE BELOW*
  3. 4-5 weeks prior to weaning: IBR, BVD, BRSV, PI3, Pasteurella (modified live vaccine MLV), worm. *See CAUTION NOTE BELOW*
  4. Weaning: IBR, BVD, BRSV, PI3, (modified live vaccine MLV), 7way blackleg booster, 5 way lepto, worm.

v  Brucellosis (Bangs) vaccine given to heifer calves between 4-12 months old. Must be administered by a veterinarian.

v  For purchased calves, give initial vaccinations at weaning or delivery. For rapid immune response, usa an intranasal IBR, PI3 treatment in addition to modified live IBR, BVD, PI3 injection.

  • Adult cows:
  1. IBR, BVD, BRSV, PI3, 5way lepto annually. Must use killed vaccine if cows are pregnant.
  2. If using natural service, vibryo given 2 weeks prior to breeding.
  3. Worm spring and fall; recommend using brand-name dewormers

CAUTION: Some MLV’s are not recommended to give to calves that are nursing cows. Always read label and consult our office if you have any questions.


  • Birth:
  1. Rota-Corona virus – orally, unless vaccinating dry cows for rota-corona
  2. Four quarts of colostrum within six hours of birth – two quarts at birth, followed four hours later with two quarts works well (reduces the number of calves which must be tubed)
  • Days 1-7:
  1. Intranasal IBR/PI3 
  • Five Weeks:
  • Eight Weeks to Two Months:
  1. Repeat: IBR, PI3, BVD, BRSV-MLV
  • Three Months:
  1. 7way Clostridium with Haemophilus
  2. Pinkeye 
  • Four to Five Months:
  1. IBR, PI3, BVD-MLV
  2. Pasteurella toxoid, may be combined 
  • Four to Ten Months:
  1. Bangs Vaccination
  2. 7way Clostridium with Haemophilus
  • Thirteen to Sixteen Months:
  1. IBR, PI3, BVD, BRSV-MLV – at least 3 weeks prior to breeding
  2. 5way Lepto, usually combined
  3. Vibrio (Camplyobacter) if bull breeding, use oil based adjuvant


  • Springer Heifer – Approximately Seven Months Pregnant
  2. 5way Lepto, usually combined
  3. E.coli toxoid, coliform mastitis vaccination
  4. Rota-Corona Virus- E.Coli, for colostral antibodies (may be combined or separate vaccines)
  5. 2 gram negative vaccine maximum
  • Close-up Heifer – Approximately Four Weeks following Springing Heifer Vaccinations
  1. E.coli toxoid, coliform mastitis vaccination
  2. Rota-Corona Virus- E.coli, for colostral antibodies
  3. 7way Clostridium

NOTE: Springer and Close-up Heifer vaccinations may need to be spread out over more time, especially in hot weather. No more than 2 gram negative vaccines at one time.

  • Fresh Heifer – 10 to 45 DIM (days in milk)
  2. 5way Lepto, usually combined
  3. E.coli toxoid


Mature Cows

  • 1-10 DIM (Days in Milk):
  1. Monitor rectal temperature for fever
  2. Monitor appetite
  3. Test milk
  4. Deworm – use a dewormer with no milk withdrawal
  5. Udder hair, switch, magnet, etc. 
  • 10-45 DIM:
  1. IBR, PI3, BVD, BRSV – MLV
  2. 5way Lepto, usually combined
  3. Vibrio (campylobacter) if bull breeding. If AI, for a period of time give vibrio prior to move to bull
  4. Prostaglandin in many breeding systems 
  • Whole Herd:
  1. 5way lepto in spring
  • Dry Off:
  1. IBR, PI3, BVD, BRSV- killed
  2. 5way lepto, usually combined
  3. E-coli toxoid for coliform mastitis
  4. Dry treat all quarters
  5. Evaluate body condition
  • Close Up:
  1. Rota virus – Corona virus – E.coli, for colostral antibodies. May be combined or separate vaccines.
  2. 7way clostridium; 8way clostridium if herd history of liver flukes
  3. E.coli toxoid for coliform mastitis
  4. Transition ration


  1. Vaccines only stimulate the immune system to produce specific antibodies. Therefore it is critical that the animals immune system is functioning.
  2. Individual herds may require additional vaccines and/or variations in the vaccination schedule.
  3. A vaccination schedule on paper that is not or cannot be adhered to will not be effective if exposure occurs.
  4. Many vaccines will not provide a high degree of protection if an overwhelming level of exposure occurs. Biosecurity should be a priority in your management decisions.


  • Foals:
  1. At 4 months: Worm
  2. At 6 months: Encephalitis, tetanus, flu, strangles, west nile. Rhino is optional; Worm (Give booster 3-5 weeks on all vaccines)
  3. Worm at weaning, then every 3 months 
  • Pregnant Mares:
  1. At 5 months pregnant: Rhino
  2. At 7 months pregnant: Rhino, encephalitis, tetanus, flu
  3. At 9 months pregnant: Rhino
  4. At 10 months pregnant: Strangles, encephalitis, rhino, flu, west nile, tetanus, worm
  5. West nile vaccine can be given at any time, with a booster in 4 weeks 
  • Adults (non-pregnant mares & geldings or stallions):
  1. At 14 months: encephalitis, tetanus, flu, strangles (then annually). West Nile, booster 3 weeks
  2. Rhino is optional at 14 months, then annually.

***Coggins at least 6 months of age***